Albert Neuberger, L. L. M. Van Deenen, Giorgio Semenza's A History of Biochemistry: Selected Topics in the History of PDF

By Albert Neuberger, L. L. M. Van Deenen, Giorgio Semenza

ISBN-10: 0444805079

ISBN-13: 9780444805072

ISBN-10: 0444807020

ISBN-13: 9780444807021

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Extra resources for A History of Biochemistry: Selected Topics in the History of Biochemistry Personal Recollections. II.

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Enzymatic s y n t h e s i s of inosinic acid de novo I am somewhat reluctant to chart the course of our research on the enzymatic synthesis of inosinic acid in any detail since this has been the topic of several reviews [63-65] and of a recent historical paper presented in one of the sessions of the American Society of Biological Chemists in connection with the fiftieth anniversary of the Annual Reviews of Biochemistry [66]. However, in my opinion these studies together with our work on the purine precursors constitute my principal contribution to science.

1 had never had any experience in bacterial virology and found this summer's introduction very useful. During the next fall James Koerner from Robert Sinsheimer's laboratory and S. Varadarajan from Alexander Todd's laboratory in Cambridge, England had arrived at MIT for postdoctoral work. It was a fortunate coincidence since their scientific backgrounds complemented each other in enzyme and organic chemistry, respectively. Flaks and Cohen [158,159] had already initiated a program in the synthesis of 5-hydroxymethyl deoxycytidylic acid from methylene tetrahydrofolate and deoxycytidylic acid and were well on their way of the study of the first phageinduced enzyme to be reported, namely dCMP hydroxymethylase.

Upon coupling at this lower temperature it yields a purple-colored product. This difference in the reaction at the two temperatures turned out to be a useful property, since it permitted us to distinguish it from AICAR whose diazotized product is stable at either temperature. The A BACKWARD GLANCE 27 intermediate formed by Fraction I described above was 5'-phosphoribosyl 5-amino-4-imidazole succinocarboxamide (SAICAR), which contains an aspartyl residue. Upon reaction with Fraction II carbon atoms of this residue are split off as fumarate.

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A History of Biochemistry: Selected Topics in the History of Biochemistry Personal Recollections. II. by Albert Neuberger, L. L. M. Van Deenen, Giorgio Semenza


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